Our project aims to revolutionize DNA sequencing technology by developing a cutting-edge System on Chip (SoC) equipped with a high-speed, low-power mixed-signal readout array. This Digital Read-Out Integrated Circuit (DROIC) system features advanced analog front-end circuitry, including a discrete-time Transimpedance Amplifier (DT-TIA) and active Correlated-Double Sampler (CDS), designed to amplify, filter, and digitize nanopore signals with unprecedented accuracy and speed. Our innovative design also incorporates column ADCs for enhanced channel density, allowing multiple amplifiers to share a single ADC and optimizing space utilization on the chip. By implementing a parallel processing scheme and using the SKYWater 130-nm Technology, we aim to achieve efficient data transmission and analysis, ultimately contributing to the development of scalable, high-throughput DNA sequencing platforms with wide-ranging applications in genomic research and biotechnology.  |   https://github.com/EMIL-YORKU/SeqSoc_Chipalooza