creativebioarray

creativebioarray/3DCellCulture

Creative Bioarray can provide ready-to-use 3D cell cultures generated from various cell types. We have extensive experience in developing highly functional 3D cell culture models. Our scientific team can work with you to establish and optimize protocols, as well as design custom 3D cell culture models according to your specific requirements.

creativebioarray/3DCocultureModels

3D co-culture cell models now serve as important tools for solving scientific questions, which can be developed in different formats, depending on research goals and downstream usage. Co-culture cell models can emulate a variety of pathological conditions such as different stages of tumor invasion and metastasis, and identify of stromal components associated with pathological process.

creativebioarray/Adipocytes

Adipocytes are cells specialized in storing energy in the form of fat, mainly triglycerides, in organelles called lipid droplets. There are two major types of adipocytes in mammals: white adipocytes contain one large lipid droplet and are involved in fat storage, while brown adipocytes have many smaller lipid droplets and numerous mitochondria that generate energy, maintaining body temperature.

creativebioarray/ADME

Creative Bioarray offers comprehensive in vitro ADME services for drug discovery organizations. Many of our in vitro ADME assays come in a variety of formats to suit different stages of the drug discovery pipeline, enabling us to provide a flexible approach to our ADME services. While Creative Bioarray has standard procedures for each of these assays listed below, our experienced research team can also help design the best strategies and protocols customized to meet any drug discovery needs.

creativebioarray/BioanalyticalServices

Creative Bioarray develops and performs rapid, sensitive and robust bioanalytical methods for the extraction and quantitation of drugs and metabolites in biological fluids and tissues to support preclinical research. We provide cost-effective design and implementation of in vivo pharmacokinetic studies in various animal species and quick turnaround of results. Our bioanalytical capabilities serve every stage of your molecular development.

creativebioarray/Biofluids

Biofluids represent an ideal source of material for biomarker development projects. Extracellular DNA, RNA, and some proteins are stably maintained in cell-free biofluid samples, even when sample processing is not optimal. In addition, biofluids derived from the respiration, digestion, or excretion are able to be collected routinely with minimal disruption to the patient’s health and daily schedule.

creativebioarray/BloodCellIsolation

Creative Bioarray has the ability to successfully isolate and culture various types of blood cells from different species. More specific subsets of blood cells can be isolated and used in biological assays and therapeutic applications. We have established mature protocols to provide ideal cells with fast turnaround time upon your request.

creativebioarray/CellCoCulture

Creative Bioarray can provide cell co-culture services of various cell types according to customer's requirement. We have the ability to co-culture multiple cell types used for various applications, such as cancer study, drug discovery and development, tissue engineering, and developmental biology.

creativebioarray/CellImmortalization

Creative Bioarray provides cell immortalization services based our experienced scientists and elaborate technical platforms. We have successfully immortalized cells from multiple tissues and species. We have the ability to meet all your needs.

creativebioarray/CellImmortalizationkit

Immortalizing the cell line will eliminate the frequent need to re-establish fresh cultures from specimens. Immortalized cell lines are capable of extended proliferation and should possess similar or identical genotype and phenotype to the parental tissue.

creativebioarray/Chemokines

Chemokines

creativebioarray/CytochromeP450

Human cytochrome P450 (CYP450) enzymes play an essential role in drug metabolism. Even subtle changes in the activities of CYP enzymes may cause severe drug-drug interactions. Creative Bioarray aims to help our clients with evaluating the interaction potential of your compounds.

creativebioarray/EHEBCellLine

Established from the peripheral blood of a 69-year-old woman with B-CLL (chronic lymphocytic leukemia) prior treatment by EBV-transformation in 1988; cell line may represent rather a B-lymphoblastoid cell line than a bona fide B-CLL cell line

creativebioarray/EpidermalGrowthFactors

Epidermal Growth Factor (EGF) is a low molecular mass protein produced in a variety of tissues and cells. In tissue culture, EGF reduces or eliminates the need for serum and can be used in combination with other media additives and hormones. EGF has a variety of biological activities, including induction of cell proliferation, differentiation, migration, and morphological determination, and has important physiological and pathological roles.

creativebioarray/ExosomesIdentification

Creative Bioarray provides exosome identification services for biological samples and purified exosomes samples. This service provides a variety of method-based solutions to facilitate researchers with different testing purposes. Our platform has established a variety of mature protocols to support your exosome research, from isolation to characterization.

creativebioarray/FFPETissue

Formalin-fixed paraffin-embedded (FFPE) tissue specimens are mainly used by the medical community and researchers to preserve biopsy samples in formaldehyde and then embed them into paraffin wax blocks. This process preserves the proteins and structures of the tissue. After storing it into a block, thin slices of the FFPE block can be made and is then mounted on a microscope slide to enable examination.

creativebioarray/FibroblastGrowthFactors

Fibroblast Growth Factor (FGF) is a class of cell growth factors. 23 members of the FGF family have a wide range of mitogenic and cell survival activities and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. Aberrant activation of the signaling pathway is associated with the onset and progression of many diseases, including cancer, diabetes, and cardiovascular disease. Therefore, FGF and its receptors may become new targets for the treatment of these diseases.

creativebioarray/Flow-Cytometry

Flow cytometry is a technology that is used to analyze the optical and fluorescence characteristics of particles as they pass through the laser beam. The cell components are fluorescently labelled and then excited by the laser to emit light at different wavelengths. The fluorescence can be measured to determine various properties of individual particles, which are usually cells. Properties measured include the particle’s relative granularity, size and fluorescence intensity as well as its internal complexity. Up to thousands of particles per second can be analyzed as they pass through the liquid stream, and an optical-to-electronic coupling system is used to record how the particle emits fluorescence and scatters incident light from the laser. Flow cytometer has numerous applications in science, including GFP expression analysis, ploidy analysis, immunophenotyping, cancer diagnosis, cell sorting, and cell counting.

creativebioarray/FrozenTissue

Frozen tissues samples have been widely used in medical research for cancer and other diseases to examine cell morphology, disease status, intracellular and intercellular communication, as well as biopsy tissue sections.

creativebioarray/HDLM2

Established from the pleural effusion of a 74-year-old man with Hodgkin lymphoma (nodular sclerosing, stage IV) in 1982

creativebioarray/Human-CD19-B-Cells

B cells are a subset of lymphocytes that express clonally diverse cell surface immunoglobulin receptor. The B cell population is a vital component of the humoral immune response. B cell activation leads to antigen uptake and presentation, affinity maturation and class switching of the immunoglobulins, and antibody secretion. Purified human B cells are an excellent source of cells to study the biology of B cells and their role in the immune system. However, B cells constitute only a small portion (~5%) of the peripheral lymphocyte population, making it difficult to obtain sufficient B cell quantities for many research applications. The ability to isolate and expand B cell populations ex vivo is valuable to researchers who require B cells for downstream applications.

creativebioarray/ImmuneCellIsolation

Creative Bioarray can successfully isolate and culture various types of immune cells from biological samples from different species. Using cytology techniques can isolate more specific immune subgroups and use them in bioassays and treatments. We have established a mature agreement and can provide separation and cultivation services with fast turnaround time according to your requirements.

creativebioarray/iPSCDerivedCells

Advances in human induced pluripotent stem cell (iPSC) technology have allowed the generation of donor-derived healthy and diseased cell lines, enabling the study of human disease phenotypes that are challenging to replicate in animal models.

creativebioarray/lenti

Immortalizing the cell line will eliminate the frequent need to re-establish fresh cultures from specimens. Immortalized cell lines are capable of extended proliferation and should possess similar or identical genotype and phenotype to the parental tissue.

creativebioarray/MetaboliteCharacterization

Creative Bioarray has deep expertise in the profiling, identification and structural characterization of metabolites in vitro and in vivo. We use advanced technology and software for accurate, reliable metabolite identification and structural characterization. In addition, synthetic chemistry services are available to undertake synthesis of metabolites, reference standards, and internal standards to aid in method development and metabolite identification.

creativebioarray/M-FISH-Analysis

Multicolor FISH (M-FISH) assays are used for a precise assessment of complex chromosomal rearrangements. This technique uses all whole-chromosome painting probes in multiplex-FISH and spectral karyotyping. Thus, marker chromosomes, complex chromosomal rearrangements, and all numerical aberrations can be visualized simultaneously in a single hybridization experiment. M-FISH is a kind of versatile tool for precise chromosome separation and for rapid chromosome classification help speeding up the workflow. Apart from that, the analysis of M-FISH images is easy even if aberrations are involved.

creativebioarray/MhhCall3

Established from the bone marrow of an 11-year-old girl with pre B cell acute lymphoblastic leukemia (ALL) in 1993 (at diagnosis)

creativebioarray/mitochondrial

JC-1 mitochondrial membrane potential assay is a fluorescence-based method to track the behavior of mitochondria. Mitochondrial membrane potential (MMP) is an important parameter of mitochondrial function that has been used as an indicator of cell apoptosis.

creativebioarray/MorrisWaterMaze

The Morris water maze is a classic behavioral test of assessing the hippocampal-dependent learning process and spatial memory for rodents.

creativebioarray/Mouse-Astrocytes-MA

Astrocytes are the most numerous and diverse glial cells in the central nervous system (CNS). Astrocytes are divided into two main subtypes on the basis of differences in their cellular morphologies and anatomical locations: protoplasmic or fibrous. Protoplasmic astrocytes exhibit a morphology of many fine branches, which are expressed in a uniform globoid distribution, and are found throughout all grey matter. Fibrous astrocytes exhibit a long fiber-like morphology and are found throughout all white matter. Studies indicate that both protoplasmic and fibrous astrocytes make extensive contacts with blood vessels and form gap junctions between the distal processes of adjacent astrocytes.

creativebioarray/pdbiomarker

Biomarkers contribute to the understanding of drug action patterns, can be involved in response to therapeutic management assessment, and are directly related to pharmacokinetic (PK) endpoints.

creativebioarray/physicochemical

Creative Bioarray provides Physicochemical Characterization Assays to help customers accurately evaluate compounds' physicochemical properties such as solubility and stability, Reducing drug development difficulties.

creativebioarray/PrimaryCellIsolation

With extensive experience in isolating and culturing primary cells from various tissues and organs, Creative Bioarray can provide a wide range of primary cells to be used as more biologically relevant tools in your research. We can offer customized services upon the requests of our customers.

creativebioarray/StableCellLineConstruction

Creative Bioarray has many years of experience in stable cell line construction services. Our gene-editing platform can successfully achieve gene knockout, knock-in, low expression, overexpression, silencing and other operations. Use the most cutting-edge technology and equipment to provide you with solutions for genetically modified stable cell lines. We have established a mature agreement and can provide you with edited stable cell lines according to your requirements.

creativebioarray/TC-71

TC-71 established from the tumor of a 22-year-old man with metastatic Ewings sarcoma that arose in the humerus; cell line was derived in 1981 from a biopsy of recurrent tumor at the primary site.

creativebioarray/TumorCellIsolation

Creative Bioarray can successfully isolate and culture primary tumor cells from different types of cancer tissues and circulating cancer cells from blood samples. Realize long-term and efficient primary tumor cell culture and use it for bioassay and therapeutic applications. We have established a mature agreement to provide ideal cells with a fast turnaround time according to your requirements.

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