creativebiogene

creativebiogene/Bacilluslicheniformis

Creative Biogene is a leading biotechnology company offering the best Bacillus licheniformis genome editing services. With years of experience and expertise in microbial genome editing, our talented scientists will work closely with you to provide any help in Bacillus licheniformis genome editing services.

creativebiogene/Bacillusthuringiensis

Creative Biogene is a leading biotechnology company offering the best Bacillus thuringiensis genome editing services. With years of experience and expertise in microbial genome editing, our talented scientists will work closely with you to provide any help in Bacillus thuringiensis genome editing services

creativebiogene/CellBankCharacterization

Creative Biogene provides a comprehensive cell bank characterization service for customers to ensure the biosafety and control of biological and biotechnological products. Based on leading-edge facilities and excellent platform, our experienced staff offer a wide range of assays to character cell bank according to ICH guideline Q5D. At Creative Biogene, we perform cell bank characterization services for different needs, including master cell bank, working cell bank and end of production cell bank. Reliable, rapid and accurate results will be delivered to assist customers to assess the quality of cell banks.

creativebiogene/circularmrna

With the development of RNA vaccines, the improvement of the stability of RNAs has been a great challenge. Fortunately, circular RNAs show great potential ahead of this challenge. The structural advantage of circular RNAs brings it higher stability, especially against the degradation of exonucleases. Endogenously produced circular RNAs are 2 to 5 times more stable than linear RNAs. Thus, circular RNAs are being studied vigorously as a new class of potential therapeutic agents.

creativebiogene/CRISPRasgRNAVectors

CRISPR/Cas9 PlatformCB provides customized CRISPRa sgRNA vectors construction services, including sgRNA design and viral vector packaging, which can be applied to both easy-to-transfect cells and hard-to-transfect cells.

creativebiogene/CRISPRCas9mediatedGenome

Creative Biogene is a leading company offering the best CRISPR/Cas9-mediated genome editing service. Our talented scientists have extensive experience in gene knockout, knock-in/replacement and site-directed mutagenesis. They would research closely with you to offer help in microbial genome editing.

creativebiogene/CustomtRNASynthesis

IntegrateRNA, as a leading biological commercial company, is dedicated to serving customers with high-efficiency and high-quality services. We offer many modified nucleotides commonly found in tRNA with Fluorescent dye and Biotin/Thiol labeled, and also offer customized services to help you achieve a trouble-free tRNA research experience.

creativebiogene/dNTPs

Creative Biogene, as a leading biotechnology service vendor in the world, possesses sophisticated equipments, advanced technologies and highly experienced staffs which are available to provide serious of high-quality dNTP products to satisfy your various needs. Creative Biogene has confident in providing you with the most affordable, high-quality dNTP products in a short turnaround time.

creativebiogene/EndotoxinRemovalKit

Creative Biogene's Easy™ Endotoxin Removal Kit is an efficient endotoxin removal tool. The final endotoxin level can be reduced below 0.1 EU/ml with repeated use of Easy™ Endotoxin Removal resin. The kit can be used to remove endotoxin from proteins, peptides, antibodies, or even DNA samples.

creativebiogene/Full-Length-cDNA-Library

Full-length enriched cDNA libraries from Creative Biogene are produced using a proprietary method which combines cDNA synthesis and amplification, thus can enrich the representative cDNA with full-length sequences even from small amount of starting materials.

creativebiogene/Functional-Gene-Sequencing

As a global leader, Creative Biogene is dedicated to provide functional gene sequencing service. With our strong expertise and decades of experience, talented specialists and comprehensive portfolio of sequencing platforms, Creative Biogene technologies provides versatile approaches to meet your needs. Our talented experts have extensive experience to give us unique insight into functional gene research.

creativebiogene/GelClotEndotoxinAssayKit

Gel Clot Endotoxin Assay Kit is designed as a simple and sensitive in vitro end–product endotoxin test for human and animal parenteral drugs, biological products, and medical devices. The kit utilizes the Limulus Amebocyte Lysate (LAL) test, which is a qualitative test method for Gram-negative bacteria endotoxin. The sensitivity of LAL in this kit is 0.25 EU/ml.

creativebiogene/GeneExpressionCellLines

The overexpression of proteins is critical for many applications, including studying the function of the gene, and in functional assays and screens. Mammalian cells offer advantages in post-translational modification and protein folding that are crucial in the production of eukaryotic proteins such as antibodies, recombinant proteins etc. Stable cell lines overexpressing specific proteins have integrated GOI in the genome and are costly and vital assets for life science research.

creativebiogene/hpv

Creative Biogene High-Risk Human Papillomavirus(HPV)Genotyping Real Time PCR Kit is used for the detection of High-risk HPV Genotypes in genital swabs, cervical cells and paraffin section samples by using real time PCR systems. An HPV infection is caused by human papillomavirus, a DNA virus from the papillomavirus family, of which over 170 types are known. The kit contains a specific ready-to-use system for the detection of the High-Risk Human Papillomavirus. Fluorescence is emitted and measured by the real time systems' optical unit during the PCR.

creativebiogene/hpvgenotyping

Creative Biogene High-Risk Human Papillomavirus(HPV)Genotyping Real Time PCR Kit is used for the detection of High-risk HPV Genotypes in genital swabs, cervical cells and paraffin section samples by using real time PCR systems. An HPV infection is caused by human papillomavirus, a DNA virus from the papillomavirus family, of which over 170 types are known. The kit contains a specific ready-to-use system for the detection of the High-Risk Human Papillomavirus. Fluorescence is emitted and measured by the real time systems' optical unit during the PCR.

creativebiogene/KnockoutMouseGeneration

CRISPR/Cas9 PlatformCB offers gene knockout mouse generation services for our clients. With experienced scientists and excellent gene editing platform, our staff has successfully generated various gene KO mice by using CRISPR/Cas9. We provide a one-stop KO mouse generation service that covers from sgRNA design and construct, pronuclear microinjection to Founders genotyping and breeding. We are dedicated to utilize the latest technology to service our customers for achieving their goals.

creativebiogene/lpsbio

Lipopolysaccharides (LPS), also known as endotoxins, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen outer core and inner core joined by a covalent bond (Figure 1). They are found in the outer membrane of Gram-negative bacteria and elicit strong immune responses in normal mammalian cells. LPS is heat stable endotoxin and has long been recognized as a crucial factor in septic shock (septicemia) in humans. The lipid A moiety has been identified as key to the endotoxin activity of LPS.

creativebiogene/Luciferase

Luciferase Reporter Cell Line - NALM6 is engineered to stably overexpress luciferase reporter gene. It is an ideal positive control for use in bioluminescence assays. In addition, NALM6 cells form tumors post implantation into immunocompromised mice. The in vivo growth of these tumors can be monitored using bioluminescent imaging.

creativebiogene/MALDI-TOFMS

Creative Biogene is a leading company offering the high-quality matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) services. Mass spectrometry (MS)-based technologies, particularly MALDI-TOF, has emerged as a potential tool for rapid, sensitive, accurate, and cost-effective microbial identification of common as well as esoteric bacteria and fungi.

creativebiogene/MicrobialCell-surfaceDisplay

Microbial cell surface display technology holds great strategic potential for expressing heterologous proteins or polypeptides with a distinct function on the surface of microbial cells. To gain amenable cell surface exposure, the passenger protein could be fused with various anchoring motifs (carrier protein), which are usually cell-surface proteins or their fragments. Up to the characteristics of passenger and carrier proteins, this strategy can be carried out using different fusion methods, such as C-terminal fusion, N-terminal fusion or sandwich fusion. Creative Biogene provides various cell-surface display systems for the successful display of a target protein or peptide on the surface of bacteria via genetic fusion to anchoring motif.

creativebiogene/MicrobialGene

Creative Biogene is a leading company offering the best microbial gene expression service. Backed by years of development and research experience, our talented scientists will help you achieve your research goals quickly and efficiently. They would research closely with you to offer your one stop service in microbial gene expression system. All you need to do is simply provide the gene sequences.

creativebiogene/MicrobialGeneExpression

Creative Biogene is a leading company offering the best microbial gene expression service. Backed by years of development and research experience, our talented scientists will help you achieve your research goals quickly and efficiently. They would research closely with you to offer your one stop service in microbial gene expression system. All you need to do is simply provide the gene sequences.

creativebiogene/MicrobialGenomeEditing

Creative Biogene is pleased to introduce the microbial genome editing service for knock-in, knock-out or gene replacement in bacteria and fungus. Our service employs a gene editing system to target up to five genes simultaneously, ensuring the accuracy down to the base pair.

creativebiogene/Microbial-Metabolomics

Creative Biogene is a service provider of microbial metabolomics. With advanced instruments and state-of-the-art multivariate data analyses, metabolomics aims to identify biomarkers, elucidate mode-of-action, characterize products and processes. Creative Biogene´s LC-MS, GC-MS and NMR based metabolomics solutions perfectly match the demands for integrated metabolic profiling, sample throughput, compound identification, validation and quantification. With the aim of obtaining metabolome data representing the physiological status of a microorganism, well-verified protocols and analysis are essential1.Creative Biogene solutions for metabolomics are specifically tailored to your research purposes, coupling innovative hardware with versatility in data processing that allows to you achieve the specific answers you seek.

creativebiogene/miRNAClones

Creative Biogene has developed an advanced vector-based miRNA expression plasmids, which can help to ease the difficulty in your research. These purified and ready to transfect miRNA expression plasmids can be used for a variety of applications to down-regulate gene expression. Besides, we can also provide miRNA mimics and inhibitors which enhance or block miRNA regulation of target gene expression. Especially miRNA inhibitors, they are designed and optimized for miRNA loss of function study.

creativebiogene/mRNAInVitroSynthesis

IntegrateRNA provides tailored mRNA synthesis for research use, at milligram to multigram scales, with lengths up to multiple kilobases. We have professional mRNA synthesis platform, and our service include gene synthesis, template preparation, RNA synthesis, purification, and quality control. The experienced RNA scientist in our company offers personalized consulting and designing service, and our RNA products with high purity and quality will meet your need.

creativebiogene/mrnasynthesis

Synthetic mRNA has recently come into focus as a potential new drug class to deliver genetic information. Such synthetic mRNA can be engineered to transiently express proteins more rapidly and safety, due to no need of transnuclear localization and lack of integration into host cell genome.

creativebiogene/mRNA-Synthesis

Creative Biogene, as one of the leading biotechnology companies, can offer the dedicated service for the production of high quality mRNAs. With the help of our highly experienced staffs, Creative Biogene is able to synthesis custom mRNAs at microgram to multigram scales, with lengths ranging from a few hundred nucleotides to kilobases. Creative Biogene's goal is to provide you with the most affordable, high-quality custom mRNA synthesis service to ensure your satisfaction in a timely and professional manner.

creativebiogene/mSlc5a5

mSlc5a5 Overexpression Stable Cell Line-B16F10 is engineered to stably overexpress mouse Slc5a5. It is an ideal positive control for use in iodine uptake assays. In addition, B16F10 cells can form metastases in mouse lungs. The in vivo growth of metastases can be monitored using PET/SPECT imaging.

creativebiogene/Nucleic-Acids-Research

Nucleic acids are the most important part of all biomolecules. The term nucleic acid is the overall name for DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). Nucleic acids research forms a foundation for modern biological research. Additionally, nucleic acids extraction and quality assessment play a critical role in the field of molecular biology, since the quality and yield of nucleic acids can affect the performance in downstream assays directly. Our different extraction procedures and instruments for extraction of nucleic acids from a broad range of different Microbial species enable to accelerate your research.

creativebiogene/oligonucleotideconjugationkit

Based on expertise in the synthesis, bioconjugation and purification, IntegrateRNA offers custom antibody-oligonucleotide conjugates (AOCs) for global customers. We have developed methods to link the oligos to the target antibody via terminal functional groups such as protected sulfhydryls, maleimide. To deliver high-quality conjugates and maximize performance for your application, IntegrateRNA offers various options for purification and characterization of AOCs, including analytical size exclusion chromatography, PAGE gel analysis, mass spec, RP-HPLC and LC-MS, depending on the AOCs and your requirements.

creativebiogene/OncolyticVirus

Oncolytic viruses (OVs) are a class of viruses that can selectively replicate in and lyse cancer cells, and subsequent spread with a tumor while not causing damage to normal cells. They have tremendous therapeutic potential to target and kill cancerous cell. Oncolytic virotherapy is an innovative treatment modality which uses replication competent viruses to destroy malignant cancers.

creativebiogene/pcrgradient

Gradient PCR instrument with advanced peltier-based semiconductor technology, High performance global universal power supply

creativebiogene/PointMutationMouse

Point mutation mouse models are widely used to study the role of specific nucleotides or amino acids in genetic elements or proteins, as well as to mimic human genetic diseases. CRISPR / Cas9 technology provides a very efficient tool to generate point mutations in mouse models, to generate precise nucleotides substitutions at target sites.

creativebiogene/ProteinPurification

Creative Biogene can provide a variety of protein purification technical services, including lab-scale protein purification, large-scale protein purification, fusion tag protein purification, and tag-free protein purification. Protein purification resins and prepacked columns are also available. Protein purification at the lab scale bridges the gap between small-scale exploratory protein purification and high-throughput operations, such as industrial-scale manufacturing. Each stage of protein purification presents different challenges during scale-up, a result of prolonged fermentation times and higher cell densities in large-scale cell cultures.

creativebiogene/retrovirus

Retrovirus: requires active cell division. In addition, there is a significant risk of integration into the host genome, leading to mutation of genes or activation of onco-genes in the host system, which is a concern for scientists.

creativebiogene/RhizopusStrain

Rhizopus is a genus of common saprophytic fungi on plants and specialized parasites on animals. Rhizopus species grow as filamentous, branching hyphae that generally lack cross-walls (i.e., they are coenocytic). Rhizopus fermentation offers a sustainable and cost-effective method for producing various products with commercial and industrial value, making it an important process in the biotechnology and food industries.

creativebiogene/sirnadrugs

Compared with small molecular drug and protein-based drug, siRNA-based drug has distinct advantages, including high specificity, high potency and reduced toxicity. It also provides a strong option for those undruggable and untaggable targets of small molecules and antibodies. In addition, siRNA-based drug plays an important role in developing personalized anticancer therapeutics. Such personalized medicine is likely to be more effective in controlling the cancer, thereby improving the success rate of cancer drugs.

creativebiogene/siRNASynthesis

siRNAs are a class of double-stranded RNA molecules that play a role in the RNAi pathway, which interfere with the expression of specific genes by post-transcriptional degradation of mRNAs that contain complementary sequences. siRNA can be used as a tool for studying single gene function in vivo and in vitro, and siRNA has attracted attention as a potential therapeutic agent due to its ability to inhibit specific genes in many diseases.

creativebiogene/SterilityTesting

Creative Biogene provides a sterility testing service for biologics, pharmaceuticals and medical devices in accordance to the guideline of USP, EP, JP and BP. With leading-edge clean room and procedure, our experienced scientists will provide convincing and reliable sterility testing services.

creativebiogene/YeastcGMP

Compared with other cell factories, Pichia pastoris is well established to produce human-like proteins that can be glycosylated intracellularly with appropriate folding. It has a rapid growth rate and can produce high yields of recombinant proteins. Pichia pastoris is suitable for production of recombinant proteins and is a viable alternative to mammalian cells.

creativebiogene/YeastGeneExpression

Creative Biogene is a leading company offering high-quality yeast gene expression service for our esteemed clients around the world across both academic institutions and biotech/pharmaceutical industries. With our strong technical force, unparalleled customized service and fast delivery time, Creative Biogene specializes in providing more cost-effective gene expression service to accelerate the global research in microbial enzymes.

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